Nanotechnology presents a range of options to lead to biology. Listed here I'll current illustrations wherever nanofabrication – a chance to make confined buildings with Proportions at will – is made use of to look at the biophysics of one molecules and cells. I'll existing some illustrations from our lab:

Our group research bacterial mobile division which is aiming to represent a ‘bottom up biology’ in synthetic cells which can autonomously divide. Our key fascination lies in cell division, chromatin composition, and spatial Regulate.

The subsequent articles are merged in Scholar. Their combined citations are counted only for the initial write-up.

Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on one molecules and steel clusters

De sterke polarisatie in de discussie rond schepping/evolutie en meer algemeen rond geloof/wetenschap lijkt helaas geen eind te kennen. Toch is er wel degelijk een heilzame middenweg, maar deze krijgt around het algemeen weinig aandacht. Dit boek kan hier wellicht verandering in brengen. Wie de geschiedenis van de relatie tussen geloof en wetenschap in duikt, komt tot verrassende inzichten. De moderne mens leeft satisfied veel stereotypen die historisch niet verantwoord blijken te zijn. Afgezaagde typeringen als ‘Vroeger dachten we dat de

SMC complexes https://www.ceesdekker.net can move physical roadblocks bigger than their ring sizing, indicating a nontopological system for DNA loop extrusion

We use nanofabricated microfluidic constructions to pattern spatial boundaries for germs and biomimetic vesicles with reconstituted protein networks and this evaluate the elemental purpose of spatial confinement for the molecular and mobile stage. Our assignments contain the following:

Dynamic ParB–DNA interactions initiate and manage a partition condensate for bacterial chromosome segregation

The rotors harness energy from the nanoscale drinking water and ion flow that may be produced by a static chemical or electrochemical prospective gradient within the nanopore, which happen to be recognized through a salt gradient or used voltage, respectively. These artificial nanoengines self-Manage and run autonomously in physiological circumstances, suggesting tips on how to setting up Power-transducing motors at nanoscale interfaces.

It was throughout this period that Dekker performed exploration on magnetic spin devices and on sound in superconductors and semiconductors.

Testing pseudotopological and nontopological designs for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments

Mother nature Physics thanks the nameless reviewers for their contribution into the peer overview of this get the job done.

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Example (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in gray, the rim on the pore is highlighted in pink, plus a 3D rendering of the motion of your DNA rod is displayed.